vPilot PTT not working Full Screen MSFS2020

Hello! I haven’t flown on Vatsim for quite some time, and decided this evening to do a flight. I had to re-download vPilot and set everything up (PC reformat since last time I used it) - all working perfectly, could get PDC set up and working, the only issue I had is that when in my sim in full screen mode, my assigned PTT key doesn’t work. It always used to work in full screen mode before, has there been anything changed? Or, am I going mad?

I don’t remember anything changing, but when I hear about keys not working, I immediately wonder, are you running vPilot and your sim both as an Administrator?